Title : Association of metabolic health and reproductive health among women
Metabolic health is associated with reproductive health among women. Women with metabolic health problems include overweight, obesity, fatty liver, diabetes, and metabolic syndrome. These metabolic disturbances result in mitochondria dysfunction, endothelial dysfunction, insulin resistance, hyperinsulinemia, hyperglycemia, and dyslipidemia. Its pathogenesis has impacts on pathophysiology of hypothalamus, pituitary, adrenal and ovary functions resulting in reproductive hormone imbalance, decreasing of luteinizing and follicle stimulating hormone, and increasing of testosterone. Examples of association of metabolic health and reproductive health among women are polycystic ovary syndrome, infertility, endometrium carcinoma, and breast cancer.
Due to ovary dysfunction, women with polycystic ovary syndrome (PCOS) have hyperandrogenism, follicular arrest, anovulation, abnormal menstruation. Other manifestations include acne, hirsutism, frontal alopecia. Women with PCOS are more likely to have gestational diabetes, hypertensive disorders, type 2 diabetes, coronary heart disease, chronic kidney disease and its related complications.
Manifestations of metabolic-reproductive health problems and its complications affect life expectancy and quality of life among women worldwide. Research evidences show that obesity shorten life expectancy among women for 10 years because of chronic illness that include diabetes complications, stroke, renal failure and heart failure.
Understanding of the association of metabolic health and reproductive health problems would be helpful of promotion of modification of healthy behaviors including dietary pattern, physical activities and exercise. Avoiding foods and drinks containing high fructose corn syrup, sugar, transfat and animal fat should be encouraged among women across the life span. Active physical activities and daily exercise should be recommended for all. As a result, metabolic and reproductive health problems among women would be decreased and their quality of life should be improved.