Title: Analysis of related factors affecting the therapeutic effect of DELP
Abstract:
Objective: To observe the therapeutic effect of DELP on blood lipid, and to explore the factors that may improve the therapeutic effect of DELP, so as to provide relevant experience for clinical treatment.
Methods: A total of 35 stroke patients admitted to the intensive care unit from January 2021 to August 2022 were selected to receive DELP treatment according to the patients' tolerance capacity and vascular conditions. By changing the number of treatment cycles and the amount of saline prefilling, The changes of triglyceride, high density lipoprotein, low density lipoprotein, total cholesterol, hematocrit, CRP and other related indexes were compared within three days before treatment and one day after treatment. By comparing the therapeutic effect, the related factors that may improve the therapeutic effect of DELP were discussed.
Results: Total cholesterol (5.01±4.10), high density lipoprotein (1.05±0.90), low density lipoprotein (2.91±2.63) before treatment, total cholesterol (3.23±2.84), high density lipoprotein (0.9±0.83), low density lipoprotein (1.79±1.63) after treatment; The differences were statistically significant (P < 0.001). DELP significantly improved patients' total cholesterol, high density lipoprotein, low density lipoprotein, and CRP. Preoperative saline prefilling was correlated with the degree of HDL change, and the more saline prefilling, the greater the degree of HDL decline (correlation coefficient =0.40, P=0.021); while the number of cycles was correlated with the degree of total cholesterol change, the more cycles, The more significant the reduction of total cholesterol was (correction correlation coefficient =0.439, correction P=0.009).
Conclusions: DELP can significantly improve total cholesterol, high density lipoprotein, low density lipoprotein and CRP, and play a positive role in the treatment of clinical patients. The number of DELP cycles was significantly correlated with the decrease degree of total cholesterol, and the amount of saline prefilling was significantly correlated with the decrease degree of HDL.
Audience take Away Notes:
• To understand the effect of patients who use DELP in neurology department
• To understand the related factors affecting the DELP effect of blood lipids
• By understanding the relevant influencing factors (such as the number of cycles, the amount of pre-filled fluid, the amount of sodium citrate, and the method of nursing) of DELP, in order to achieve better treatment and nursing effects
