Placental growth factor clinical significance

Title: Placental growth factor clinical significance

Abstract:

Objectives: The relevance of placental growth factor was analyzed at the admission of patients with acute coronary syndrome (ACS) without ST elevation in prognosis of fatal outcome after 30 days.
Methods: We collected blood samples from 102 ACS patients admitted to the coronary unit with acute chest pain manifesting within the last 12 hours.
Results: In all 102 admitted patients, higher values of placental growth factor (PLGF; >13.2 ng/L, average value) indicated a higher risk of fatal outcome (hazard ratio [HR] 2.28, 95% confidence interval [CI] 1.21- 4.76, P = 0.0125). PLGF is an important independent prognostic marker (adjusted HR 2.35, 95% CI 1.98-4.61, P = 0.1338), and this was shown in a multiparameter model, which involved other statistically important markers of relative risk (age >65, gender, and estimated glomerular filtration rate [eGFR]).
Conclusion: PLGF levels measured at 12 hours of symptom onset and 30 days later may independently predict fatal outcome in patients with ACS without ST elevation.

Biography:

Mirjana Markovic a Doctor of Pharmaceutical Science (Medical Biochemistry). She also an experienced and licensed professor of Biology. As a scientist, she wrote scientific papers published in various journals. Her expertise is based on the cardiac biomarkers and their clinical significance in predicting future outcomes in cardiovascular diseases. She also licensed professor with over 20 years of experience in educating undergraduate and graduate students (General Education, Health Science, Nursing) to reach their goals and earn their degree.