COVID-19 is a highly contagious disease, and hospital-related transmission remains a significant risk to health-care personnel. Since nurses are extremely vulnerable to COVID-19, hospital-specific policies must be established to limit the risk of infection among nurses who deal with COVID-19 patients. Nurses must ensure that all patients, regardless of their infectious condition, receive tailored, high-quality care. Exploring the challenges that nurses experience when caring for COVID-19 patients will help nurses and hospitals be more resilient in the face of the crisis, as well as improve preparedness and recovery. Furthermore, by informing leaders and decision-makers about these concerns and providing ideas and implications, nurses will be better able to support themselves.